KURT F. ZIMMERMAN, M.D.; PETER A. SCHLESINGER, M.D.; THOMAS J. BLOSS, M.D.; M. THOMAS STILLMAN, M.D.
To the editor: Kremer and associates (1), in reporting the results of their placebo-controlled crossover trial of fish oil in active rheumatoid arthritis, note that "the washout period after receipt of fish oil supplements was not long enough to prevent some carryover of benefits in patients crossing over to placebo." In their discussion they claim that this carryover "would result in an underestimation of the true differences between study groups during weeks 18 to 32, an effect that would serve to mask the possible effects of fish oil during this period." We feel the carryover effect may in fact lead
ZIMMERMAN KF, SCHLESINGER PA, BLOSS TJ, STILLMAN MT. Fish-Oil Supplementation and Rheumatoid Arthritis. Ann Intern Med. ;107:263. doi: 10.7326/0003-4819-107-2-263_1
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Published: Ann Intern Med. 1987;107(2):263.
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