J. REDON, M.D.; J. M. PASCUAL, M.D.; J. MICHAVILA, M.D.; A. BELDA, M.D.
To the editor: Drug fever is an underdiagnosed situation in part due to nonspecific clinical characteristics as reported by Mackowiak and LeMaistre (1). They wrote that ". . . any drug has the capacity to induce fever. . . . the list is a dynamic one. . . ." We have seen fever as the sole feature of adverse drug reaction by another two drugs not listed by them, (+)-cyanidanol-3 and azathioprine.
(+)-Cyanidanol-3 is a flavonoid used to treat chronic liver disease (2), which induces fever, probably by an immunologic mechanism (3). We have previously reported (4) two men with
REDON J, PASCUAL JM, MICHAVILA J, BELDA A. Drug Fever. Ann Intern Med. ;107:264. doi: 10.7326/0003-4819-107-2-264_1
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Published: Ann Intern Med. 1987;107(2):264.
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