HENRI BISMUTH, M.D.; DIDIER SAMUEL, M.D.; JEAN GUGENHEIM, M.D.; DENIS CASTAING, M.D.; JACQUES BERNUAU, M.D.; BERNARD RUEFF, M.D.; JEAN-PIERRE BENHAMOU, M.D.
Orthotopic liver transplantation was done in 17 patients with fulminant hepatitis. The cause of the liver disease was infection with hepatitis B virus, or co-infection with hepatitis B virus and hepatitis D virus, or infection with hepatitis A virus in 6 patients; drug hepatotoxicity in 5; and indeterminate in 6. Grafts from incompatible blood groups, steatotic grafts, or reduced-size grafts were used in 5, 4, and 4 patients, respectively. Of the 17 patients, 5 died: 2 of early liver failure due to the poor quality of the graft, 1 presumably of accidentally transmitted acute infection with the human immunodeficiency virus, and 2 of decerebration occurring during or immediately after surgery. The 12 other patients were alive 2 to 15 months after transplantation.
BISMUTH H, SAMUEL D, GUGENHEIM J, CASTAING D, BERNUAU J, RUEFF B, et al. Emergency Liver Transplantation for Fulminant Hepatitis. Ann Intern Med. 1987;107:337–341. doi: 10.7326/0003-4819-107-2-337
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Published: Ann Intern Med. 1987;107(3):337-341.
Gastroenterology/Hepatology, Liver Disease, Liver Transplantation.
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