JAY H. HOOFNAGLE, M.D.
Vidarabine (adenine arabinoside; Ara-A) is an adenine analogue with potent activity against several DNA viruses including most herpesviruses. In a large, multicenter trial done in the mid-1970s, vidarabine was shown to be beneficial as primary therapy of herpes simplex virus encephalitis (1). The development, evaluation, and licensure of vidarabine was an important milestone in antiviral research. Vidarabine was the first drug licensed in the United States as a major, systemic antiviral agent.
Encouraged by the potent and broad-spectrum antiviral activity of vidarabine against herpesviruses, Pollard and coworkers (2) did a small pilot study of vidarabine in patients with chronic type
JAY H. HOOFNAGLE. Antiviral Treatment of Chronic Type B Hepatitis. Ann Intern Med. 1987;107:414–415. doi: 10.7326/0003-4819-107-2-414
Download citation file:
Published: Ann Intern Med. 1987;107(3):414-415.
Gastroenterology/Hepatology, Liver Disease.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use