PAUL D. MITNICK, M.D.
To the editor: The anecdotal experiences reported by Domoto, and colleagues (1) do not warrant the recommendation that continuous arteriovenous hemofiltration be the therapy of choice for the extracorporeal removal of N-acetylprocainamide. The data shown do not clearly support the author's initial conclusion that arteriovenous hemofiltration is superior to intermittent dialysis in the removal of N-acetylprocainamide, nor do they support their far-reaching conclusion that it be the therapy of choice, alternate conclusions may be reached by using their own data.
Because true clearance or dialysance was not reported for any patient, comparative efficacy may only be derived from serum levels
MITNICK PD. N-Acetylprocainamide Toxicity. Ann Intern Med. ;107:424–425. doi: 10.7326/0003-4819-107-2-424
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Published: Ann Intern Med. 1987;107(3):424-425.
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