RICHARD T. DAVEY JR., M.D.; THOMAS B. NUTMAN, M.D.; ERIC A. OTTESON, M.D.
To the editor: We read with interest the report by Farber and Laguarda (1) of their use of serologic diagnosis in a probable case of human pulmonary nodular disease due to Dirofilaria immitis. We cannot, however, concur with their conclusion that the use of the enzyme-linked immunosorbent assay (ELISA) or other serologic assays "rather than invasive procedures, such as thoracotomy, may be indicated in similar clinical settings in geographic areas where D. immitis infestation is common." Such a conclusion is not supported by available seroepidemiologic data. In addition to the obvious problems with suboptimal sensitivity (2), the serodiagnosis
DAVEY RT, NUTMAN TB, OTTESON EA. Serodiagnosis of Dirofilarial Infection. Ann Intern Med. ;107:430–431. doi: 10.7326/0003-4819-107-2-430_3
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Published: Ann Intern Med. 1987;107(3):430-431.
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