MICHAEL D. LOCKSHIN, M.D.; AZZUDIN E. GHARAVI, M.D.
To the editor: Petri and colleagues (1) have used the antiphospholipid antibody test inappropriately. They have committed the etymologic and intellectual solecisms of predicting past events with point prevalence assays. The logical conclusion of their article is that antiphospholipid antibody does not validate remote events, a conclusion that trivializes not only this but any laboratory assay.
It is particularly disturbing that Petri and colleagues do not define or validate the clinical events they report. For instance, they do not distinguish early spontaneous abortion from the very different midpregnancy fetal death (2). They do not indicate the number of pregnancies at
LOCKSHIN MD, GHARAVI AE. Anticardiolipin Antibodies and the Lupus Anticoagulant. Ann Intern Med. ;107:431–433. doi: 10.7326/0003-4819-107-2-431
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Published: Ann Intern Med. 1987;107(3):431-433.
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