WILLIAM L. ISLEY, M.D.
Normal volunteers treated with rifampin, a potent inducer of liver microsomal enzymes, have significant decreases in serum thyroxine levels and free thyroxine index but no changes in basal or stimulated thyrotropin levels (1-3). We report the case of a patient with primary hypothyroidism receiving a constant replacement dose of L-thyroxine who developed biochemical hypothyroidism when treated with rifampin.
A 31-year-old woman with Turner syndrome and hypertension was admitted with dizziness, nausea, and vomiting. Fifteen months earlier she had had a total thyroidectomy for a rapidly enlarging goiter, which was complicated by hypoparathyroidism and recurrent laryngeal nerve palsy. Pathologic examination of
ISLEY WL. Effect of Rifampin Therapy on Thyroid Function Tests in a Hypothyroid Patient on Replacement L-Thyroxine. Ann Intern Med. 1987;107:517–518. doi: 10.7326/0003-4819-107-4-517
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Published: Ann Intern Med. 1987;107(4):517-518.
Endocrine and Metabolism, Thyroid Disorders.
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