CORNELlS HALMA, M. D.; JAN B. M. J. JANSEN, M.D., Ph.D.; A. ROELOF JANSSENS, M.D., Ph.D.; GERRIT GRIFFIOEN, M.D.; CORNELIS B. H. W. LAMERS, M.D., Ph.D.
Short-term infusion (2 hours) of somatostatin has been shown to reduce urinary volume and free-water clearance in healthy persons (1). Although somatostatin is being widely used (2), water intoxication has not been described as a side effect. We report two cases of marked water retention and hyponatremia that occurred in patients receiving somatostatin therapy (given in continuous intravenous infusion at a rate of 250 μg/h after a loading dose of 250 μg). One patient had to be treated with hypertonic saline for hypo-osmolar coma.
Patient 1, a 44-year-old woman with multiple endocrine neoplasia, type 1, had had an insulinoma and
CORNELlS HALMA, JAN B. M. J. JANSEN, A. ROELOF JANSSENS, GERRIT GRIFFIOEN, CORNELIS B. H. W. LAMERS. Life-Threatening Water Intoxication During Somatostatin Therapy. Ann Intern Med. 1987;107:518–520. doi: 10.7326/0003-4819-107-4-518
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Published: Ann Intern Med. 1987;107(4):518-520.
Endocrine and Metabolism, Fluid and Electrolyte Disorders, Nephrology.
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