JOHN A. AXELSON, M.D.; RAY H. CLARK, M.D.; SIGMUND ANCEREWICZ, M.D.
To the editor: Wegener granulomatosis is a disease characterized by necrotizing vasculitis of the upper and lower respiratory tracts, necrotizing glomerulonephritis, and differing degrees of disseminated small-vessel disease. The disease can range in severity from localized upper airway disease to the full-blown syndrome. We report the case of a patient with early Wegener granulomatosis confined to the nasal mucosa treated successfully with trimethoprim-sulfamethoxazole without previous immunosuppresant drugs.
A 16-year-old girl presented with nasal pain and epistaxis. A crusting ulcerated lesion was noted. Cultures for bacteria and fungus were negative and she failed to respond to topical and systemic antibiotics. A
AXELSON JA, CLARK RH, ANCEREWICZ S. Wegener Granulomatosis and Trimethoprim-Sulfamethoxazole. Ann Intern Med. ;107:600. doi: 10.7326/0003-4819-107-4-600_1
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Published: Ann Intern Med. 1987;107(4):600.
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