KENNETH L. COHEN, M.D.; SUSANNE HARRIS, PA-C
To the editor: The pain and discomfort of diabetic peripheral neuropathy may respond to treatment with pentoxifylline. This drug has the ability to increase erythrocyte flexibility and improve flow in the microvasculature (1). We gave pentoxifylline for 16 weeks to eight patients with type II diabetes with established nephropathy in an attempt to determine whether there would be any beneficial effect on renal function and proteinuria. Although there were no changes in glucose control (fasting blood sugar, and hemoglobin A1C levels) or renal function (blood urea nitrogen, creatinine, or 24-hour urine protein levels), six of seven patients who had painful
COHEN KL, HARRIS S. Pentoxifylline and Diabetic Neuropathy. Ann Intern Med. 1987;107:600–601. doi: 10.7326/0003-4819-107-4-600_2
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Published: Ann Intern Med. 1987;107(4):600-601.
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