THOMAS W. H. KAY, M.B. B.S. B Med Sci.; PAULA HEYMA, Ph.D.; LEONARD C. HARRISON, M.D.; F. I. R. MARTIN, M.D.
External beam radiotherapy for nonthyroidal conditions has been followed by the development of Graves disease (1, 2) and thyroid eye disease is occasionally exacerbated after radioactive iodine (3). Both occurrences may be due to release of antigen from the damaged thyroid and consequent production of stimulating thyrotropin receptor antibodies (1). After 131I treatment of thyrotoxicosis there is a dose-dependent increase in thyrotropin receptor antibodies also believed to be secondary to gland destruction (4). This finding is not generally clinically significant as the gland has been rendered unresponsive by radiation damage. In this patient, the indication for therapy was euthyroid multinodular
KAY TWH, HEYMA P, HARRISON LC, MARTIN FIR. Graves Disease Induced by Radioactive Iodine. Ann Intern Med. ;107:857–858. doi: 10.7326/0003-4819-107-6-857
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Published: Ann Intern Med. 1987;107(6):857-858.
Endocrine and Metabolism, Thyroid Disorders.
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