CHENG HWEE MING, PH.D.
To the editor: Petri and associates (1) reported a sensitive enzyme-linked immunosorbent assay (ELISA) for anticardiolipin antibody that detected reactive plasma samples, defined as having greater than 42.3 ng of bound immunoglobulin per milliliter.
In a recent international workshop on anticardiolipin antibody assay, Harris and coworkers (2) proposed the adoption of a GPL unit, the unit of activity of a standardized affinity-purified serum from a patient with a high IgG anticardiolipin antibody. Their established lower limit of sensitivity was 5 GPL units, equivalent to the binding activity of 5 µg/mL of IgG anticardiolipin antibody. By comparison, the method of Petri
MING CH. Anticardiolipin Antibody Quantitation. Ann Intern Med. ;107:941–942. doi: 10.7326/0003-4819-107-6-941_3
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Published: Ann Intern Med. 1987;107(6):941-942.
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