Ruth Neta, PhD; Joost J. Oppenheim, MD
Interleukin-1 is a hormone-like polypeptide produced in response to infection, injury, physiologic stress, or antigenic challenge. Originally named for its ability to act as an intercellular signal between leukocytes, interleukin-1 has pleiotropic effects on tissues and organs (1). Fever, elevation of acute-phase reactive proteins, and neutrophilia are some responses to systemic interleukin-1 that make it a key mediator of inflammation (2). As an inflammatory mediator, interleukin-1 may be both beneficial and harmful. Current studies focus on possible therapeutic uses of interleukin-1 itself, as well as its agonists and antagonists. Although the availability of large quantities of recombinant interleukin-1 has made
Ruth Neta, Joost J. Oppenheim. Why Should Internists Be Interested in Interleukin-1?. Ann Intern Med. 1988;109:1–3. doi: 10.7326/0003-4819-109-1-1
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Published: Ann Intern Med. 1988;109(1):1-3.
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