Nagesh G. Kavi, MD; Charles E. Mengel, MD
To the Editor: Hydrochlorothiazide is a commonly used diuretic and antihypertensive agent. Mild muscular symptoms with weakness, easy fatigability, and occasional cramps are common adverse reactions associated with this medication. These symptoms are often attributed to the presence of hypokalemia (1). Muscle spasm and muscular aches are also potential adverse reactions (2). We treated a patient who apparently had an unusually severe reaction to hydrochlorothiazide typified by an acute debilitating myalgic syndrome and chills.
A 57-year-old black man, known to be hypertensive, had been treated the previous year with hydrochlorothiazide and methyldopa with satisfactory control of his blood pressure. He
Kavi NG, Mengel CE. Hydrochlorothiazide and Myalgias. Ann Intern Med. ;109:84. doi: 10.7326/0003-4819-109-1-84
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Published: Ann Intern Med. 1988;109(1):84.
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