Leonard E. Gately III, MD; W. Abe Andes, MD
To the Editor: Danazol was initially used for inhibition of the pituitary-ovarian axis and treatment of angioedema due to deficiency of C'1 esterase inhibitor. Side effects are generally related to hormonal changes and fluid retention. Hypersensitivity reactions are not prominent. Danazol has recently been used as a therapeutic agent in some autoimmune diseases such as idiopathic thrombocytopenia and autoimmune hemolytic anemia (1-3). We report the cases of two patients who developed erythema multiforme while receiving danazol (Danocrine; Winthrop-Breon, New York, New York).
A 49-year-old man had profuse bleeding from lacerations due to a motor vehicle accident. His platelet count was
Gately LE, Andes WA. Danazol and Erythema Multiforme. Ann Intern Med. ;109:85. doi: 10.7326/0003-4819-109-1-85_1
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Published: Ann Intern Med. 1988;109(1):85.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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