Amin U. Haq, MD; Jonathan Glass, MD; Catherine V. Netchvolodoff, MD; L. Michael Bowen, MD
To the Editor: Hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu disease) is characterized by recurrent bleeding episodes, multiple telangiectasias, and familial occurrence. Treatment of this disease is unsatisfactory. Oral estrogen may be very useful in controlling the frequency and severity of epistaxis (1). However, due to the feminizing effects of estrogens, male patients may be reluctant to take the hormones. The authors were recently forced to search for an alternative treatment in a male patient who refused to take estrogen. There was marked improvement of symptoms with danazol, a synthetic weak androgen.
A 41-year-old white army veteran had severe anemia; he had a
Haq AU, Glass J, Netchvolodoff CV, Bowen LM. Hereditary Hemorrhagic Telangiectasia and Danazol. Ann Intern Med. ;109:171. doi: 10.7326/0003-4819-109-2-171_1
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Published: Ann Intern Med. 1988;109(2):171.
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