David A. Watson; Daniel M. Musher; Richard J. Hamill
To the editor: In his excellent review article on interferon-gamma, Murray (1) scrupulously avoids mentioning the controversial problem of the interaction between this lymphokine and polymorphonuclear leukocytes. Yet, whether interferon-gamma affects polymorphonuclear leukocytes remains unresolved. An answer might shed light, for example, on whether part of the host response to pulmonary infection reflects the generation by alveolar macrophages of lymphokines that influence polymorphonuclear leukocyte recruitment or function. Steinbeck and colleagues (2) suggested that pretreatment of polymorphonuclear leukocytes with interferon-gamma suppressed Chemotaxis but had no effect on phagocytosis, whereas Perussia and colleagues (3) found phagocytosis and bacterial killing to be enhanced
Watson DA, Musher DM, Hamill RJ. Interferon-Gamma and Polymorphonuclear Leukocytes. Ann Intern Med. ;109:250–251. doi: 10.7326/0003-4819-109-3-250_2
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Published: Ann Intern Med. 1988;109(3):250-251.
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