Marcelo Cantarovich, MD; Christian Hiesse, MD; Olivier Lantz, MD; Bernard Charpentier, MD; Daniel Fries, MD
To the editor: In patients with end-stage renal disease due to lupus nephritis, uremia and hemodialysis result in a "burnt-out," or clinically inactive state that no longer needs treatment. This state could be attributed to the depressive effect on the immune response secondary to azotemia (1). More than 400 functioning grafts in patients with systemic lupus erythematosus have been registered (2). The recurrence of lupus nephritis in renal allografts is rare (1, 3-5), but has been reported when transplantation was done in recipients with active disease. Thus, renal transplantation is recommended when systemic lupus erythematosus is quiescent during hemodialysis (3).
Cantarovich M, Hiesse C, Lantz O, Charpentier B, Fries D. Renal Transplantation and Active Lupus Erythematosus. Ann Intern Med. 1988;109:254–255. doi: 10.7326/0003-4819-109-3-254
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Published: Ann Intern Med. 1988;109(3):254-255.
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