Leonard C. Altman, MD; Penny E. Petersen, MD
To the Editor: The incidence of adverse systemic reactions to iron dextran is 3%; that of life-threatening reactions is 0.6% (1). We present a method for desensitization before iron dextran administration.
A 26-year-old white man had chronic malabsorption and gastrointestinal blood loss resulting in iron deficiency anemia. His hematocrit was maintained at approximately 25 by frequent transfusions; his serum ferritin was 20 ng/mL (normal range, 25 to 100). Because he was unable to absorb oral iron, intravenous iron dextran therapy was attempted. After a test dose of 0.25 mL, he rapidly developed nausea, vomiting, pruritus, diffuse erythema, and tachycardia. Approximately
Altman LC, Petersen PE. Successful Prevention of an Anaphylactoid Reaction to Iron Dextran. Ann Intern Med. ;109:346–347. doi: 10.7326/0003-4819-109-4-346
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Published: Ann Intern Med. 1988;109(4):346-347.
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