Sudhir V. Shah, MD; Vashu Thakur, MD
To the Editor: Recent studies have begun to delineate the pathophysiologic basis for the syndrome of pregnancy-associated diabetes insipidus that begins during gestation and remits after delivery (1, 2, 3). Barron and colleagues (1) described three cases of diabetes insipidus resistant to arginine vasopressin ("vasopressin-resistant diabetes insipidus of pregnancy") in pregnant women. On the basis of knowledge that placenta generates vasopressinase (4), an aminopeptidase that degrades arginine vasopressin, Barron and colleagues, as well as other researchers, have suggested that excessive production of vasopressinase may be responsible for pregnancy-associated diabetes insipidus in some patients. In a recent report, Durr and colleagues
Shah SV, Thakur V. Vasopressinase and Diabetes Insipidus of Pregnancy. Ann Intern Med. ;109:435–436. doi: 10.7326/0003-4819-109-5-435_2
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Published: Ann Intern Med. 1988;109(5):435-436.
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