Erik Hägg, MD; Kjell Asplund, MD; Jan Holm, MD
To the Editor: Acromegaly has been reported to be associated with cancer and premalignant adenomatous polyps of the colon (1, 2). We have seen three patients in whom acromegaly and multiple myeloma coexisted.
A woman born in 1918 had clinically overt acromegaly diagnosed in 1969 with high levels of serum growth hormone (GH) (46µg/L; normal, < 10), but a sellar roentgenogram was normal. She declined treatment until 1975 when pituitary irradiation therapy was given (45 Gy) with decreasing serum GH levels. In 1978, an IgG kappa myeloma stage I A was diagnosed that progressed to stage III A in 1980.
Hägg E, Asplund K, Holm J. Acromegaly and Multiple Myeloma. Ann Intern Med. ;109:437–438. doi: 10.7326/0003-4819-109-5-437_2
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Published: Ann Intern Med. 1988;109(5):437-438.
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