Frederick H. Ziel, MD; Anne L. Peters, MD
To the Editor: The long-term management of acromegalic patients should include screening for colonic polyps and colon carcinoma as reported by Klein and colleagues (1) and Ituarte and colleagues (2). This screening is especially important, as patients usually have many years of exposure to excess growth hormone and insulin-like growth factor 1, either because their diagnosis is often delayed or their response to conventional treatments is slow or incomplete (3). This prolonged exposure to excess growth factors may promote tumorigenesis (1). In the past year, the three patients with acromegaly who were treated at our endocrine clinic were found to
Ziel FH, Peters AL. Acromegaly and Gastrointestinal Adenocarcinomas. Ann Intern Med. ;109:514–515. doi: 10.7326/0003-4819-109-6-514_2
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Published: Ann Intern Med. 1988;109(6):514-515.
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