R.H.B. Meyboom; N. de Graaf-Breederveld
To the Editor: The systemic use of corticosteroids is limited by various serious side effects, including psychic disturbances, such as euphoria, depression, and manic or paranoid states (1). The advantage of administering corticosteroids by the inhalation route is that patients with asthma can benefit from corticosteroid treatment with less systemic side effects (1, 2). We report two cases of psychic side effects in patients receiving treatment with corticosteroid budesonide (Pulmicort) by the inhalation route.
A 39-year-old man without a history of psychic disturbances had attacks of bronchogenic dyspnea. Treatment with inhaled budesonide, two puffs (0.2 mg) two times daily, was
Meyboom R, de Graaf-Breederveld N. Budesonide and Psychic Side Effects. Ann Intern Med. ;109:683. doi: 10.7326/0003-4819-109-8-683_1
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Published: Ann Intern Med. 1988;109(8):683.
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