Sergio Salmeron, MD; Francois Brenot, MD; Bernardette Rain, MD; Michel Peuchemaur, MD; Philippe Herve, MD; Gerald Simonneau, MD; Pierre Duroux, MD; Bernard Rouveix, MD
To the Editor: Maprotiline (Ludiomil, Ciba Pharmaceutical Company, Summit, New Jersey) is a new tetracyclic antidepressant agent widely used in the United States and in Europe. The allergic side effects reported have included skin reactions and abnormal blood values (1). We report a case of allergic alveolitis related to maprotiline treatment.
A 66-year-old man was hospitalized with fever and dyspnea. The patient was in good health except for mild depression, and he had been taking maprotiline, 75 mg/d, for the previous 2 months. After 3 weeks of treatment, he had a fever (38.2 °C) and malaise. Because of tremors, trihexyphenidyl
Salmeron S, Brenot F, Rain B, Peuchemaur M, Herve P, Simonneau G, et al. Maprotiline and Pulmonary Alveolitis. Ann Intern Med. ;109:758–759. doi: 10.7326/0003-4819-109-9-758_2
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Published: Ann Intern Med. 1988;109(9):758-759.
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