Terry A. Jacobson, MD
To the Editor: Perrillo and colleagues (1) make an important contribution to the study of chronic hepatitis B treatment. The disappearance of the hepatitis B surface antigen (HBsAg) in 22% of treated patients is exciting and suggests the eradication of the hepatitis B infection. However, some methodologic pitfalls need further clarification. Although randomization was done before therapy, important characteristics that portend prognosis were not similar in the treatment and control groups. The serum alanine aminotransferase levels before treatment were higher in the treated group at the P less than 0.03 level, although the results of the study showed that responders
Jacobson TA. Chronic Hepatitis B. Ann Intern Med. ;109:760–761. doi: 10.7326/0003-4819-109-9-760_2
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Published: Ann Intern Med. 1988;109(9):760-761.
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