Paul Ogden, MD; Veronica K. Piziak, MD, PhD; Phillip T. Cain, MD; W.R. Carpentier, BSN, MS; David F. Havemann, MD
To the Editor: In recent years, omega-3 fatty acid (fish oil) supplementation has been widely studied for various reasons. It has been assumed that taking supplemental fish oil is innocuous; in fact, fish oil capsules are sold without Food and Drug Administration restrictions. We observed an unusual reaction to fish oil capsules not previously reported.
In November 1987, a 68-year-old white woman enrolled in a randomized study of fish oil dosage. Except for hyperlipidemia, she was healthy. She was only taking vitamin supplements. She was randomly assigned to receive three Super EPA-600 capsules daily (Pharmacaps, Inc., Elizabeth, New Jersey). She
Ogden P, Piziak VK, Cain PT, Carpentier W, Havemann DF. Reactive Lymphoid Hyperplasia after Omega-3 Fatty Acid Supplementation. Ann Intern Med. ;109:843–844. doi: 10.7326/0003-4819-109-10-843_3
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Published: Ann Intern Med. 1988;109(10):843-844.
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