Daniel M. Musher, MD
If there has seemed to be one fixed point in the therapeutic armamentarium, one axiom of medical treatment, it has been that early syphilis is cured by 2.4 mIU (million international units) of benzathine penicillin. As physicians, we have tended to overlook the fact that the major clinical trials in the treatment of syphilis utilized aqueous or procaine penicillin and, later, alum-precipitated procaine penicillin, whereas we now use benzathine penicillin. We have also tended to ignore the occasional therapeutic failure, being all too ready to attribute it to reinfection. Finally, we have been content with serologic observations rather than forcing
Musher DM. How Much Penicillin Cures Early Syphilis?. Ann Intern Med. ;109:849–851. doi: 10.7326/0003-4819-109-11-849
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Published: Ann Intern Med. 1988;109(11):849-851.
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