Yoshiaki Ohbayashi, MD; Akio Urabe, MD; Kazuo Niitani, MD
To The Editor: We report a case of adult-T-cell leukemia in a patient successfully treated with natural interferon-alpha.
A 37-year-old woman was hospitalized in March 1986 for nodular erythemas of the chest, abdomen, and extremities. The results of peripheral blood studies showed leukocytosis (20 000/mm3), with convoluted lymphocytes (70%), positive anti-human T-cell lymphotropic virus (HTLV)-I-antigen antibody, and a high CD4:CD8 ratio. Convoluted lymphocytes also infiltrated in bone marrow (26.4%). She was diagnosed as having adult-T-cell leukemia. The repeated administration of combination chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisolone failed to achieve a remission. She was hospitalized in November 1987 because
Ohbayashi Y, Urabe A, Niitani K. Adult T-cell Leukemia and Interferon-Alpha. Ann Intern Med. ;109:992. doi: 10.7326/0003-4819-109-12-992_1
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Published: Ann Intern Med. 1988;109(12):992.
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