Devenyi Paul, MD
To the editor: A growing literature is concerned with the severe complications associated with the abuse of cocaine. For example, papers on acute rhabdomyolysis (1) and on muscle and skin infarction (2) were recently published in your journal. Similar papers, too numerous to quote, have appeared in many other major journals. In addition to muscle necrosis, other reported vascular complications include thrombotic and nonthrombotic myocardial infarction, severe cardiac arrhythmias, strokes, abruptio placentae, intestinal ischemia, and occlusion of the central retinal artery (3, 4). The common denominator in these cases seems to be intense vasoconstriction caused by cocaine's inhibitory effects on
Paul D. Cocaine Complications and Pseudocholinesterase. Ann Intern Med. ;110:167–168. doi: 10.7326/0003-4819-110-2-167
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Published: Ann Intern Med. 1989;110(2):167-168.
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