Roberto Esposito, MD; Caterina Uberti Foppa, MD; Spinello Antinori, MD
The therapy for cryptococcal meningitis in patients with the acquired immunodeficiency syndrome (AIDS) is still unsatisfactory. Although other populations generally respond well to treatment with amphotericin B and flucytosine, patients with AIDS have a markedly lower cure rate (1). Moreover, after the initial therapy, long-term maintenance treatment with an antifungal agent is mandatory, because of the high frequency of recurrences. Weekly amphotericin B therapy has been recommended for this purpose, but Zuger and colleagues (2) show that some patients have relapses despite the administration of maintenance doses of the drug. On the other hand, the severity of side effects (including
Esposito R, Foppa CU, Antinori S. Fluconazole for Cryptococcal Meningitis. Ann Intern Med. ;110:170. doi: 10.7326/0003-4819-110-2-170_1
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Published: Ann Intern Med. 1989;110(2):170.
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