Jordi Altés, MD; Joan Gascó, MD; Josep de Antonio, MD; Ana Salas, MD; Concepción Villalonga, MD
To the editor: The new quinolone antibacterial agents are being increasingly used in many infectious diseases. Their effectiveness and safety seem to make them acceptable, although close surveillance for new adverse effects is encouraged (1).
Cases of central nervous system toxicity have been reported in association with norfloxacin (2), enoxacin (3) and pefloxacin (4) treatment. The percentage of adverse reactions of the central nervous system related to ciprofloxacin has been estimated to be 1.6 (1). The more frequently reported central nervous system symptoms were headache, restlessness, tremors, dizziness, and insomnia. Three cases of possibly drug-related hallucinations have been reported (5).
Altés J, Gascó J, de Antonio J, Salas A, Villalonga C. Ciprofloxacin and Delirium. Ann Intern Med. ;110:170–171. doi: 10.7326/0003-4819-110-2-170_2
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Published: Ann Intern Med. 1989;110(2):170-171.
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