Paul R. Cheney, MD, PhD; Susan E. Dorman; David S. Bell, MD
To the editor: The chronic fatigue syndrome (the chronic mononucleosis syndrome, the chronic Epstein-Barr virus syndrome) is a recently described illness with numerous symptoms of unknown cause (1, 2). Abnormalities of natural killer function and decreased enhancement of cytotoxicity in the presence of interleukin-2 have been found (3). The results of recent studies (4) of cancer treatment with recombinant interleukin-2 alone and in combination with autologous lymphokine-activated killer cells have documented side effects that superficially resemble manifestations of the chronic fatigue syndrome. For this reason, we undertook a preliminary study of interleukin-2 plasma levels in two geographically separate groups of
Cheney PR, Dorman SE, Bell DS. Interleukin-2 and the Chronic Fatigue Syndrome. Ann Intern Med. 1989;110:321. doi: 10.7326/0003-4819-110-4-321_1
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Published: Ann Intern Med. 1989;110(4):321.
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