David W. Bentley, MD; Shyam D. Karki, PharmD; Robert F. Betts, MD
To the editor: The withdrawal of anticonvulsant drugs in patients free of seizures for more than 2 years has been recommended recently (1). Because of similar concerns about the long-term toxic effects of the anticonvulsant drugs, we have begun to withdraw treatment from selected patients in nursing homes whom we have seen at our hospital for chronic diseases. During a recent prospective, double-blind trial of rimantadine hydrochloride to prevent influenza A infection, two patients developed seizures. We emphasize the risk of influenza chemoprophylaxis for induction of seizures in the seizure-prone patient.
A 39-year-old man with cerebral palsy and mental retardation
Bentley DW, Karki SD, Betts RF. Rimantadine and Seizures. Ann Intern Med. ;110:323–324. doi: 10.7326/0003-4819-110-4-323_2
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Published: Ann Intern Med. 1989;110(4):323-324.
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