P. Fievet, MD; M. Boudjelal, MD; R. Demontis, MD; P. Veyssier, MD; P. Y. Lallement, MD; N. Bove, MD; P. Ronco, MD
To the editor: Hemorrhagic fever with renal syndrome, which was recognized in France in 1982, is related to Puumala virus (1). The main histologic disorders of the kidney are medullar diffuse edema with interstitial hyperemia and hemorrhage, vacuolization and swelling of tubular epithelial cells, and the presence of cell casts (2). The intensity of these lesions varies, and the mechanism of renal insufficiency is still incompletely understood. In other diseases, such as multiple myeloma with renal failure, deposits of Tamm-Horsfall protein are present in the urinary spaces of glomeruli (3). Tamm-Horsfall protein is produced by epithelial cells of the thick
Fievet P, Boudjelal M, Demontis R, Veyssier P, Lallement PY, Bove N, et al. Hemorrhagic Fever with Renal Syndrome and TammHorsfall Protein. Ann Intern Med. ;110:325. doi: 10.7326/0003-4819-110-4-325_1
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Published: Ann Intern Med. 1989;110(4):325.
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