Samuel Broder, MD
The acquired immunodeficiency syndrome (AIDS) and its related disorders are caused by a retrovirus now called human immunodeficiency virus, type 1 (HIV-I) (1). Four years ago, pathogenic retrovirus infections were viewed by many scientists and clinicians as inherently untreatable. This idea militated against offering patients, or society at large, even the most cautious sense of optimism, and scientists assumed the uncomfortable role of preparing the public for the worst. The prevailing view was that there might not be anything worth testing in large-scale clinical trials and that for the foreseeable future no therapy would make a substantial impact against the
Broder S. Controlled Trial Methodology and Progress in Treatment of the Acquired Immunodeficiency Syndrome (AIDS): A Quid ProQuo. Ann Intern Med. ;110:417–418. doi: 10.7326/0003-4819-110-6-417
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Published: Ann Intern Med. 1989;110(6):417-418.
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