Edwin J. Gyorffy, MD; James E. Bredfeldt, MD; William C. Black, MD
Although there is a causal relation between the use of oral contraceptives and hepatic cell adenoma (1), a similar relation between the use of oral contraceptives and hepatocellular carcinoma remains speculative. Studies of hepatocellular carcinoma in young women using oral contraceptives and other epidemiologic evidence suggest a possible causal relation (2-5). A more fundamental question is whether hepatic cell adenomas are premalignant and can transform into hepato-cellular carcinoma. We report the case of a long-term user of oral contraceptives in whom a hepatic cell adenoma, as shown by a biopsy sample, transformed into hepatocellular carcinoma.
A 53-year-old white
Gyorffy EJ, Bredfeldt JE, Black WC. Transformation of Hepatic Cell Adenoma to Hepatocellular Carcinoma Due to Oral Contraceptive Use. Ann Intern Med. 1989;110:489–490. doi: 10.7326/0003-4819-110-6-489
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Published: Ann Intern Med. 1989;110(6):489-490.
Gastroenterology/Hepatology, Gastrointestinal Cancer, Hematology/Oncology, Liver Cancer, Liver Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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