Andrea Salmi, MD
To the Editor: As Di Bisceglie and colleagues ( 1 ) stressed in their article on hepatocellular carcinoma, the widespread use of high-resolution ultrasound in combination with alpha-fetoprotein measurements makes it possible to detect tumors as small as 1 to 2 cm in diameter (2) through careful follow-up of patients with cirrhosis. Surgical treatment is often not advisable because of the relative frequency of advanced cirrhosis (1). Therefore, because we lack an efficient therapy, the efforts spent in diagnosing small tumors may be useless. For this reason, several new treatments for the disease have been proposed. The results of recent
Salmi A. Percutaneous Alcohol Injection of Hepatocellular Carcinoma. Ann Intern Med. ;110:494. doi: 10.7326/0003-4819-110-6-494
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Published: Ann Intern Med. 1989;110(6):494.
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