Robert T. Rolfs, MD; Jonathan M. Zenilman, MD; Harold W. Jaffe, MD
To the editor: Lukehart and associates (1) have confirmed previous reports that the central nervous system is commonly involved in patients with primary and secondary syphilis. Also, they have shown that in some patients, Treponema pallidum may persist in the central nervous system after the recommended benzathine penicillin therapy has been given. Although the number of patients coinfected with human immunodeficiency virus (HIV) who had cerebrospinal fluid evaluation after treatment was small, these data, along with those from reports of neurosyphilis in HIV-infected patients (2), suggest that patients coinfected with HIV may be at increased risk for neurosyphilis.
Robert T. Rolfs, Jonathan M. Zenilman, Harold W. Jaffe. Treatment of Neurosyphilis. Ann Intern Med. 1989;110:574–575. doi: 10.7326/0003-4819-110-7-574_2
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Published: Ann Intern Med. 1989;110(7):574-575.
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