Carolyn R. O'Connor, MD; Thomas M. O'Dorisio, MD
To the Editor: Initially, somatostatin analogues were reported to be effective in treating secretory diarrhea that occurs in Werner-Morrison syndrome and carcinoid syndrome (1). Recently, a long-acting somatostatin analogue (SMS 201-995, octreotide acetate, Sandostatin) has been reported to be beneficial in treating other types of diarrhea (2, 3). We report the case of a patient with primary systemic amyloidosis who had diarrhea refractory to conventional treatment and whose symptoms were controlled with administration of SMS 201-995.
A 78-year-old man had a 6-month history of weight loss, anorexia, and six watery bowel movements daily. There was no family history of amyloidosis
O'Connor CR, O'Dorisio TM. Amyloidosis, Diarrhea, and a Somatostatin Analogue. Ann Intern Med. ;110:665–666. doi: 10.7326/0003-4819-110-8-665
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Published: Ann Intern Med. 1989;110(8):665-666.
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