J. A. del Olmo, MD; J. V. Bagan; J. M. Rodrigo; M. A. Serra; A. H. Wassel; L. Aparisi; M. Bixquert
To the Editor: Recent reports have described the association of chronic liver disease and lichen planus (13); however, there is uncertainty about the prevalence of chronic liver disease in patients with lichen planus (4, 5). We carried out a prospective study of 65 patients diagnosed macro- and microscopically as having oral lichen planus. Each patient was examined and a complete medical history including information about the ingestion of potentially hepatotoxic drugs was obtained. Each patient was tested for transaminases, alkaline phosphatase, gamma-glutamyl transpeptidase, protein, and serologic markers for hepatitis B virus. When we suspected chronic liver disease because of hepatosplenomegaly
del Olmo JA, Bagan JV, Rodrigo JM, Serra MA, Wassel AH, Aparisi L, et al. Oral Lichen Planus and Hepatic Cirrhosis. Ann Intern Med. ;110:666. doi: 10.7326/0003-4819-110-8-666_1
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Published: Ann Intern Med. 1989;110(8):666.
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