Cesare Masala, MD; Maurizio Sorice, MD; Maria A. Di Prima, MD; Luisa Lenti, MD; Roberta Misasi, MD; Carlo Contini, MD; Vincenzo Vullo, MD
To the Editor: Misra and colleagues (1) reported an increased incidence of anticardiolipin antibodies in patients with infectious mononucleosis and postulated the existence of cross-reactions between infectious (viral) antigens and cardiolipin. We report here our experience concerning immunologic and biochemical similarities between Pneumocystis carinii organisms and cardiolipin. We observed that in the acquired immunodeficiency syndrome (AIDS), anticardiolipin antibodies occurred almost exclusively among those patients who had active P. carinii pneumonia (2). To test the cross-reactive hypothesis, we did several experiments.
In the first set of experiments, rabbits were immunized with an antigen from P. carinii in Freund's adjuvant prepared according
Masala C, Sorice M, Di Prima MA, Lenti L, Misasi R, Contini C, et al. Anticardiolipin Antibodies and Pneumocystis carinii Pneumonia. Ann Intern Med. ;110:749. doi: 10.7326/0003-4819-110-9-749_1
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Published: Ann Intern Med. 1989;110(9):749.
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