Mark Monane, MD; Gary S. Gabelman, MD; Ellen Cohen, MD; Jill P. Karpel, MD
To the Editor: Chambers and colleagues (1) reported cure rates of 94% and 33% in episodes of right-sided Staphylococcus aureus endocarditis treated with 2 weeks of nafcillin-tobramycin, and vancomycin-tobramycin, respectively. The enrollment group included 17 patients with endocarditis who were dropped from study analysis when exclusionary criteria developed during treatment. We question the reported cure rates and the pragmatic approach to dropout analysis (2) adopted by Chambers and colleagues.
In order to include these dropouts in the study analysis, one should assume the broadest range of circumstances. In this formulation, all 17 episodes would be cured or not cured. Using
Monane M, Gabelman GS, Cohen E, Karpel JP. Right-Sided Staphylococcal Endocarditis. Ann Intern Med. ;110:749–750. doi: 10.7326/0003-4819-110-9-749_2
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Published: Ann Intern Med. 1989;110(9):749-750.
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