Terry Linville, MD; Dean Matanin, PharmD
To the Editor: Norfloxacin (Noroxin, Merck Sharp & Dohme, West Point, Pennsylvania) was the first of the fluorinated quinolone group of antimicrobial agents to be released by the Food and Drug Administration. Noroxin is a fluorinated quinolone derivative structurally related to nalidixic acid (NegGram, Winthrop/Breon, New York, New York). Nalidixic acid was originally synthesized in 1962 and is the prototype of a class of drugs known as quinolones. When compared with nalidixic acid, norfloxacin has a quinolone ring in place of a 1,8-napthyridine molecule. The addition of a 1-piperazinyl group at the 7-position of the quinolone ring confers antipseudomonal activity
Linville T, Matanin D. Norfloxacin and Warfarin. Ann Intern Med. ;110:751–752. doi: 10.7326/0003-4819-110-9-751_2
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Published: Ann Intern Med. 1989;110(9):751-752.
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