Alan M. Sugar, MD; Carol Saunders, RN; Beldon A. Idelson, MD; David B. Bernard, MD
To the Editor: Fluconazole is a new azole orally administered antifungal agent with a broad spectrum of activity (1). This drug may prove useful in treating infections due to Candida and other fungal pathogens common in organ transplantation recipients. We feel it is important to identify any interaction between fluconazole and cyclosporine, because ketoconazole, a closely related antifungal, has been reported to increase serum concentrations of cyclosporine to potentially toxic levels (2-4), and similar interactions may occur with another new azole antifungal, itraconazole (5).
A 46-year-old diabetic woman received a kidney donated by a living relative 15 months before admission.
Sugar AM, Saunders C, Idelson BA, Bernard DB. Interaction of Fluconazole and Cyclosporine. Ann Intern Med. ;110:844. doi: 10.7326/0003-4819-110-10-844_1
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Published: Ann Intern Med. 1989;110(10):844.
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