Robert A. Weinstein, MD
In this issue, Brun-Buisson and coworkers (1) report the use of oral antibiotics for intestinal decontamination in an outbreak of infection with multiply-resistant Enterobacteriaceae (predominantly Klebsiella species) in a French medical intensive care unit. They found that patients in the study had less intestinal colonization and infection with the epidemic strains than historical and concurrent controls; however, decontamination produced no beneficial effect on overall rates of nosocomial infection in the unit.
The use of oral, nonabsorbable antibiotics for selective tive decontamination in endemic and hyperendemic gram-negative bacillary infections in intensive care units has been evaluated for almost 20 years (2-7).
Weinstein RA. Selective Intestinal Decontamination-An Infection Control Measure Whose Time Has Come?. Ann Intern Med. ;110:853–855. doi: 10.7326/0003-4819-110-11-853
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Published: Ann Intern Med. 1989;110(11):853-855.
Gastroenterology/Hepatology, Infectious Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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