John T. Daugirdas, MD; Nouhad O. Kronfol, MD; Antonios H. Tzamaloukas, MD; Todd S. Ing, MD
Nonketotic hyperosmolar coma is a syndrome found mostly in diabetic patients with marked hyperglycemia; the relative pathogenetic roles of hyperglycemia, hyperosmolality, and cellular (especially brain) dehydration in causing the comatose state have not been fully delineated (1-3). Examination of recent reports of dialysis patients with extreme hyperglycemia who were not comatose (4-6), and re-analysis of descriptions of nondialysis patients with nonketotic hyperosmolar coma (1) can help us better understand the proposed causes for hyperosmolar coma.
Hyperglycemia has an important indirect pathogenetic role (1-3); in patients with adequate renal function, hyperglycemia initiates an osmotic diuresis (7) that continues until stopped by
Daugirdas JT, Kronfol NO, Tzamaloukas AH, Ing TS. Hyperosmolar Coma: Cellular Dehydration and the Serum Sodium Concentration. Ann Intern Med. ;110:855–857. doi: 10.7326/0003-4819-110-11-855
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Published: Ann Intern Med. 1989;110(11):855-857.
Endocrine and Metabolism, Fluid and Electrolyte Disorders, Nephrology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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