André Delannoy, MD; Myriam Géhenot, MD
To the Editor: In a recently published UCLA conference (1), Golde reviewed the therapeutic applications of colony-stimulating factors. We suggest that some patients with drug-induced agranulocytosis may also benefit from this experimental therapy.
A 65-year-old woman was hospitalized because of dipyrone-induced agranulocytosis. Her leukocyte count was 800/¼ L, with 10 neutrophils, 720 lymphocytes, 10 basophils, and 60 large lymphocytes (day 0). No myeloid cells were found in the bone marrow. Human recombinant granulocyte-macrophage colony-stimulating factor (GM-CSF), 400 μg daily, was administered intravenously from day 1 to day 4. The neutrophil and immature granulocyte counts increased rapidly from 40/¼L (day 1)
Delannoy A, Géhenot M. Colony-Stimulating Factor and Drug-Induced Agranulocytosis. Ann Intern Med. ;110:942–943. doi: 10.7326/0003-4819-110-11-942_2
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Published: Ann Intern Med. 1989;110(11):942-943.
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