Peter James Cronkright, MD; Gregory Szymaniak, BSc, PharmD, RPH
To the Editor: Acute rhabdomyolysis can be caused by various drugs, usually by overdosing (1-4). However, cases resulting from isoniazid therapy have not previously been reported. A 25-year-old obese black woman had begun voiding dark brown urine for 4 days before admission (this lasted 2 days and subsided after forcing oral fluids). She also had bilateral calf pain and general malaise that started two days preceding admission and had had a sore throat for 2 days approximately 2 weeks before admission. She had no history of other symptoms of upper respiratory infection, fever, arthralgias, rash, or cough, and no gastrointestinal
Cronkright PJ, Szymaniak G. Isoniazid and Rhabdomyolysis. Ann Intern Med. ;110:945. doi: 10.7326/0003-4819-110-11-945_1
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Published: Ann Intern Med. 1989;110(11):945.
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