Brian F. O'Kelly, MB; Barry M. Massie, MD; Julio F. Tubau, MD; Jadwiga Szlachcic, MD
Experimental findings in animals and epidemiologic studies in humans provide strong evidence that hypertension promotes the onset and progression of atherosclerosis. However, effective antihypertensive therapy has not consistently reduced the incidence of cardiac events in the major trials of treatment for mild hypertension. In reviewing these trials and the recent data on the pathophysiologic interrelationships among hypertension, atherosclerosis, and myocardial ischemia, two factors stand out: First, the power of these trials to produce a positive result was limited because of their size, entry criteria, duration, and other considerations; second, autopsy and epidemiologic data suggest that some patients in these trials
O'Kelly BF, Massie BM, Tubau JF, Szlachcic J. Coronary Morbidity and Mortality, Pre-existing Silent Coronary Artery Disease, and Mild Hypertension. Ann Intern Med. ;110:1017–1026. doi: 10.7326/0003-4819-110-12-1017
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Published: Ann Intern Med. 1989;110(12):1017-1026.
Cardiology, Coronary Heart Disease, Coronary Risk Factors, Hypertension, Nephrology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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